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Evidence is increasing that most addiction without exception is related to problems with the brain's reward center, especially the mesolimbic system. This part of the problem regulates reward responses in getting food and sex, along with nurturing infants and children. One of the most important neurotransmitters involved with reward responses, both once they malfunction and when they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in reply to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to shed pounds can be very effective you can find combinations in front of the FDA now awaiting approval. When dealing with weight loss and the people that go through it one should err along the side of caution and permit the FDA do its job and demand some investigation be done in order that the public understands the side effects and hazards of the medications before we take them. Keep in mind that drug companies have been in business to make money and that they would say almost anything to keep people on the medications. Researchers found that participants investing in this drug for any year, lost excess weight within a month and have kept the extra weight off throughout the 56 weeks from the study. Contrave is really a combination with the drugs naltrexone and bupropion, which appears to reflect a brand new trend of weight-loss drugs which are made up of multiple active ingredient, which might make them far better and safer. Combo-pilling is the newest fad or in addition to this the newest in the future under scrutiny and thus it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular could be the fact that as of right now there are no long term prescription slimming capsules that have been authorized by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications although some people might of the combinations happen to be rejected or have yet to be approved by the FDA. Seizures certainly are a side effect with Contrave and must not be taken in people who have seizure disorders. The drug can also raise blood pressure levels and heartrate, and mustn't be used in those with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure and heart rate and must not be used in patients with uncontrolled high blood pressure, and also by you aren't heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients with a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert medical professionals and patients for the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stopping smoking. A pyromaniac, with both psychiatric and medical therapy, can still be treated. It is best done with behavioral therapy. Psychotherapy treatment alongside behavior modification is regarded as the frequently used treatment. Based on the study of Jon Grant, a compounding treatment of drugs and behavioral therapy is discovered to be successful in treating pyromania. The using serotonin reuptake inhibitors can be beneficial in controlling the impulsive behavior from the patient like other impulse control disorder. Also ideal for the patient are medications for example Lithium, naltrexone, (ReVia), fluoxetine (Prozac), citalopram (Celexa), paroxetene (Paxil), along with other antidepressants.